iDQC anisotropy map imaging for tumor tissue characterization in vivo
Rosa T. Branca, Yuming M. Chen, Vladimir Mouraviev, Gigi Galiana, Elizabeth R. Jenista, Challa Kumar, Carola Leuschner, Warren S. Warren
Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue. Magn Reson Med, 2009. © 2009 Wiley-Liss, Inc.
Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue. Magn Reson Med, 2009. © 2009 Wiley-Liss, Inc.
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