Hyperpolarized carbon–carbon intermolecular multiple quantum coherences

Journal of Magnetic Resonance
Article in Press, Corrected Proof

Hyperpolarized carbon–carbon intermolecular multiple quantum coherences

Elizabeth R. JenistaCorresponding Author Contact Information, a, E-mail The Corresponding Author, Rosa T. Brancaa and Warren S. Warrena
aCenter for Molecular and Biomolecular Imaging, 2220 French Family Science Center, Duke University, Durham, NC 27708, USA

Received 17 July 2008;
revised 17 September 2008.
Available online 2 October 2008.

Abstract

Intermolecular multiple quantum coherences (iMQCs) can provide unique contrast with sub-voxel resolution. However, the characteristic growth rate of iMQCs mostly limits these effects to either hydrogen or hydrogen-coupled systems for thermally polarized samples. Hyperpolarization techniques such as dynamic nuclear polarization (DNP) allow for significant increases in the carbon signal (even more signal than that from hydrogen), making carbon iMQCs achievable. We present the first intermolecular multiple quantum signal between two carbon nuclei.

Keywords: Intermolecular multiple quantum coherence; 13C hyperpolarization; Dynamic nuclear polarization; MultiCRAZED; CRAZED