Hyperpolarized carbon–carbon intermolecular multiple quantum coherences

Journal of Magnetic Resonance
Article in Press, Corrected Proof

Hyperpolarized carbon–carbon intermolecular multiple quantum coherences

Elizabeth R. JenistaCorresponding Author Contact Information, a, E-mail The Corresponding Author, Rosa T. Brancaa and Warren S. Warrena
aCenter for Molecular and Biomolecular Imaging, 2220 French Family Science Center, Duke University, Durham, NC 27708, USA

Received 17 July 2008;
revised 17 September 2008.
Available online 2 October 2008.

Abstract

Intermolecular multiple quantum coherences (iMQCs) can provide unique contrast with sub-voxel resolution. However, the characteristic growth rate of iMQCs mostly limits these effects to either hydrogen or hydrogen-coupled systems for thermally polarized samples. Hyperpolarization techniques such as dynamic nuclear polarization (DNP) allow for significant increases in the carbon signal (even more signal than that from hydrogen), making carbon iMQCs achievable. We present the first intermolecular multiple quantum signal between two carbon nuclei.

Keywords: Intermolecular multiple quantum coherence; 13C hyperpolarization; Dynamic nuclear polarization; MultiCRAZED; CRAZED

Accurate Temperature Imaging Based on Intermolecular Coherences in Magnetic Resonance

Science 17 October 2008:
Vol. 322. no. 5900, pp. 421 - 424
DOI: 10.1126/science.1163242

Accurate Temperature Imaging Based on Intermolecular Coherences in Magnetic Resonance
Gigi Galiana, Rosa T. Branca, Elizabeth R. Jenista, and Warren S. Warren

Conventional magnetic resonance methods that provide interior temperature profiles, which find use in clinical applications such as hyperthermic therapy, can develop inaccuracies caused by the inherently inhomogeneous magnetic field within tissues or by probe dynamics, and work poorly in important applications such as fatty tissues. We present a magnetic resonance method that is suitable for imaging temperature in a wide range of environments. It uses the inherently sharp resonances of intermolecular zero-quantum coherences, in this case flipping up a water spin while flipping down a nearby fat spin. We show that this method can rapidly and accurately assign temperatures in vivo on an absolute scale.

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