Effect of Hypercapnia on the iDQC Response
Abstract of talk 117 from ISMRM 2005 Meeting (need password for access)
A. Schäfer, S. Zysset, W. Heinke, H. E. Möller
To date the origin of the fMRI signal change based on intermolecular double quantum coherences (iDQC) is not well understood. The aim of this work was to investigate the sensitivity to global changes of the cerebral blood flow (CBF) of this method. Global CBF changes can be induced by changing the arterial partial pressure of carbon dioxide due to hypercapnia. While the number of activated voxels was significantly decreased, the percentage signal change was roughly seven-fold increased in iDQC-based imaging as compared to conventional BOLD contrast.
A. Schäfer, S. Zysset, W. Heinke, H. E. Möller
To date the origin of the fMRI signal change based on intermolecular double quantum coherences (iDQC) is not well understood. The aim of this work was to investigate the sensitivity to global changes of the cerebral blood flow (CBF) of this method. Global CBF changes can be induced by changing the arterial partial pressure of carbon dioxide due to hypercapnia. While the number of activated voxels was significantly decreased, the percentage signal change was roughly seven-fold increased in iDQC-based imaging as compared to conventional BOLD contrast.
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